#Grapefruit juice interactions free#

However there has been a lack of awareness of its effects on other medications in patients as well as physicians. Since the accidental discovery of its interaction with felodipine, more than 85 drugs have been identified to have the potential to cause serious adverse reactions. The use of grapefruit juice on its own or in a mixture with other juices is gradually increasing in UK and grapefruit juice is now a regular part of breakfast consumption in most of Western Europe and America.

Grapefruit juice sales are gradually increasing since 1970s and reached an average of 24.9 million litres per annum between 20.

^ a b David Tanis, Heart of the Artichoke and Other Kitchen Journeys ( Workman: 2010), p.

^ Salvatore Calabrese, Classic Cocktails ( Sterling Publishing, 1997), p.

'Why Grapefruit and Medication Can Be a Dangerous Mix'.

^ a b c d e f Mitchell, Steve (19 February 2016).

'Grapefruit-medication interactions: forbidden fruit or avoidable consequences?'.

^ a b Bailey DG, Dresser G, Arnold JM (March 2013).

Journal of the American Dietetic Association. 'Nutrient content and nutrition labeling of several processed Florida citrus juice products'.

^ Fellers PJ, Nikdel S, Lee HS (August 1990).

^ The World's Healthiest Foods Grapefruit.

It must contain 0.7% to 2.1% of acid by weight as anhydrous citric acid. During the production process, the sugar content in the juice, before the addition of sugar, invert sugar, dextrose or glucose solids, should have a Brix reading of no less than 9.3.

#Grapefruit juice interactions free#

According to Canadian standards, grapefruit juice should contain more than 1.15 milliequivalents of free amino acid per 100 millilitres (3.5 imp fl oz 3.4 US fl oz) more than 70 milligrams of potassium per 100 ml and have an absorbance value for total polyphenolics of no less than 0.310. Canadian regulations Ĭanadian regulations on commercially produced and sold grapefruit juice are that it must be made from clean, mature grapefruit and may contain sugar, invert sugar, dextrose, glucose solids and class II preservatives such as benzoic acid, amylase, cellulase and pectinase. Grapefruit juice is used in several cocktails, such as the sea breeze (which consists of grapefruit juice, vodka, and cranberry juice) the salty dog, the grapefruit mimosa, and a grapefruit radler. People taking drugs can ask their health care provider or pharmacist questions about grapefruit/drug interactions. Drugs which are incompatible with grapefruit are typically labeled on the container or package insert.

One whole grapefruit or a glass of 200 mL (6.8 US fl oz) of grapefruit juice can cause drug overdose toxicity. The other effect is that grapefruit can block the absorption of drugs in the intestine, and if the drug is not absorbed, then not enough of it is in the blood to have a therapeutic effect.

This happens in two ways: one is that grapefruit can block an enzyme which metabolizes medication, and if the drug is not metabolized, then the level of the drug in the blood can become too high, leading to an adverse effect. Grapefruit and grapefruit juice have been found to interact with numerous drugs, in many cases resulting in adverse effects. Main article: Grapefruit–drug interactions